Influence of the method of Fluosol-DA administration on antipyrine metabolism in the rat-Reference-Cited by-同舟云学术

Influence of the method of Fluosol-DA administration on antipyrine metabolism in the rat

Published:1990-11 Issue:11 Volume:42 Page:813-816
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Shrewsbury Robert P¹,White Lisa G²

Affiliation:

1. School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA

2. College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA

Abstract

Abstract Antipyrine disposition has been determined in the rat following administration of Fluosol-DA by an intravenous infusion without blood removal or a haemodilution procedure, and compared with data from sham haemodiluted rats (blood removed and returned) and control rats which only received antipyrine. Antipyrine total body and renal clearance and the formation clearance of two of its metabolites were affected differently at 48 h by the pretreatments. The haemodilution procedure enhanced, the sham haemodilution reduced, and the intravenous infusion had no effect on the phenobarbitone inducible cytochrome P450 isoenzyme activity.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/42/11/813/37237918/j.2042-7158.1990.tb07031.x.pdf

Reference17 articles.

1. Effect of inflammation and proadifen on the disposition of antipyrine, lignocaine and propranolol in rat isolated perfused liver;Chindavijak;J. Pharm. Pharmacol.,1987

2. Effect of inflammation on the metabolism of antipyrine, lidocaine and propranolol in isolated rat hepatocytes;Chindavijak;Pharmacology,1988

3. Comparative characterization of isolated forms of cytochrome P-450 inducible by phenobarbital and perfluorodecalin;Grishanova;Biokhimiya,1988

4. Phenobarbital type of induction of cytochrome P-450 of liver microsomes by perfluorodecalin;Grishanova;Biokhimiya,1987

5. Effects of intravenous emulsified perfluorochemicals on hepatic cytochrome P-450;Huang;Biochem. Pharmacol.,1987

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Acute Effects of Moderate Fluosol-DA Hemodilution on Hepatic Microsomal and Nonmicrosomal Metabolism in Rats;Biomaterials, Artificial Cells and Immobilization Biotechnology;1992-01