A single injection of a biodegradable microsphere formulation of the ACTH-(4–9) analogue ORG 2766 accelerates functional recovery after brain damage-Reference-Cited by-同舟云学术

A single injection of a biodegradable microsphere formulation of the ACTH-(4–9) analogue ORG 2766 accelerates functional recovery after brain damage

Published:1990-07 Issue:7 Volume:42 Page:508-510
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Wolterink Gerrit¹,Bouwman Theo R M²,Eenink Mart J D²,De Nijs Henrik²,van Ree Jan M¹

Affiliation:

1. Rudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht, Vondellaan 6, 3521 GD Utrecht, The Netherlands

2. Pharmaceutical R&D Laboratories, Organon International B. V., AKZO Pharma Division, P.O. Box 20, 5340 BH Oss, The Netherlands

Abstract

Abstract The functional recovery from impaired motor activity induced by 6-hydroxydopamine lesions in rat nucleus accumbens was accelerated by subcutaneous treatment with the ACTH-(4–9) analogue Met/O2/-Glu-His-Phe-D-Lys-Phe (ORG 2766). Treatment was effective after daily injections of ORG 2766 dissolved in saline during the first 6 days following the lesion (ED50: 28.5 ng kg−1 day−1) or after a single injection of the peptide in a biodegradable microsphere formulation administered after the lesion (ED50:8.9 ng kg−1 day−1). This study shows that a single injection of a microsphere preparation can replace multiple injections with ORG 2766 in order to facilitate functional recovery after brain damage.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/42/7/508/37238296/j.2042-7158.1990.tb06607.x.pdf

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