Moisture Adsorption-desorption Effect on the Structure of Inclusion Complex of 6-Chloro-2-pyridylmethyl Nitrate and β-Cyclodextrin-Reference-Cited by-同舟云学术

Moisture Adsorption-desorption Effect on the Structure of Inclusion Complex of 6-Chloro-2-pyridylmethyl Nitrate and β-Cyclodextrin

Published:1990-09 Issue:9 Volume:42 Page:611-614
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Kitamura Satoshi¹,Koda Shigetaka¹,Yasuda Tsutomu¹

Affiliation:

1. Analytical Research Laboratories, Fujisawa Pharmaceutical Co. Ltd, 1-6 2-Chome Kashima, Yodogawa-ku, Osaka 532, Japan

Abstract

Abstract A new anti-anginal drug, 6-chloro-2-pyridylmethyl nitrate (FR46171), was found to form a complex with β-cyclodextrin (β-CyD), molecular ratio 1:1. The FR46171/β-CyD complex thus prepared showed a moisture adsorption-desorption hysteresis characteristic of hydrophilic polymers. The moisture adsorption-desorption isotherm and differential scanning calorimetry indicated that the moisture adsorbed FR46171/β-CyD complex includes 13–15 mol of water while the moisture desorbed complex includes 5 mol of water. X-ray diffraction patterns of these samples confirmed their different structures. The scanning electron photomicrographs and the surface areas (BET) suggested that the moisture adsorption-desorption hysteresis observed in FR46171/β-CyD complex can be attributed to reversible hydrogen bonding between water molecules and hydroxyl groups.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/42/9/611/37238498/j.2042-7158.1990.tb06617.x.pdf

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