Oxidative deamination of aliphatic amines by rat aorta semicarbazide-sensitive amine oxidase-Reference-Cited by-同舟云学术

Oxidative deamination of aliphatic amines by rat aorta semicarbazide-sensitive amine oxidase

Published:1990-12 Issue:12 Volume:42 Page:882-884
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Yu Peter H¹

Affiliation:

1. Neuropsychiatric Research Unit, Department of Psychiatry, Cancer and Medical Research Building, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 0W0 Canada

Abstract

Abstract Rat aorta semicarbazide-sensitive amine oxidase (SSAO) exhibits very high affinity in the deamination of an homologous series of aliphatic amines of 1 to 18 straight chain carbon atoms. The Km value decreases substantially as the chain length of these amines increases. The Vmax values are higher for the short chain amines. Diamines are poor substrates for SSAO or are not acted upon by the enzyme. The substrate preference for SSAO differs from that for monoamine oxidase.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/42/12/882/37237846/j.2042-7158.1990.tb07048.x.pdf

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