Renal Responses to Magnesium Lithospermate B-Reference-Cited by-同舟云学术

Renal Responses to Magnesium Lithospermate B

Published:1990-10 Issue:10 Volume:42 Page:712-715
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Yokozawa Takako¹,Lee Tae Woong¹,Chung Hae Young²¹,Oura Hikokichi¹,Nonaka Gen-Ichiro³¹,Nishioka Itsuo³¹

Affiliation:

1. Department of Applied Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-01, Japan

2. College of Pharmacy, Pusan National University, Pusan, Korea

3. Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812, Japan

Abstract

Abstract Renal responses to magnesium lithospermate B isolated from Salviae miltiorrhizae radix were examined in normal rats. Urinary sodium, potassium, prostaglandin E2 and kallikrein excretion was significantly increased after magnesium lithospermate B administration, whereas excretion of urinary 6-keto-prostaglandin F1α and thromboxane B2 was unchanged. Rats administered with the drug also revealed a slight elevation of plasma renin activity and the levels of angiotensins I and II. Plasma aldosterone was decreased slightly. No significant changes were observed in angiotensin-converting enzyme or blood pressure.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/42/10/712/37237008/j.2042-7158.1990.tb06565.x.pdf

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