Affiliation:
1. School of Studies in Pharmacology, University of Bradford, Bradford 7, UK
Abstract
Abstract
Previous reports that cortisone and related compounds exerted a small degree of protection against antigen-aerosol-induced anaphylactic reactions, have been confirmed. Optimal effects were obtained 16 to 24 h after corticosteroid pretreatment. Marked effects were obtained from the more potent glucocorticoids, particularly water-soluble compounds. Similar pretreatment decreased the severity and modified the form of anaphylactic bronchoconstrictor responses induced by intravenous administration of antigen. In guinea-pigs pretreated also with mepyramine, the corticosteroids suppressed the residual and presumably non-histamine component of the anaphylactic bronchoconstrictions. Anti-anaphylactic potency was correlated with glucocorticoid and anti-inflammatory activity. A suggested mode of action involves a combination of weak anti-histamine activity and inhibition of release of slow reacting substances of anaphylaxis.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
14 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献