Some observations of the penetration and disruption of tablets by water

Abstract

Abstract The effect of compressibility, particle size, granulation and the addition of starch on the pore structure on tablets of aspirin, calcium carbonate, lactose, magnesium carbonate, phenindione and sucrose has been measured using air permeability and liquid penetration techniques. The addition of starch to the various materials produced no significant effect on the pore structure of the dry tablet but caused disruption and alteration of this structure when the tablet was penetrated by water. This disruptive effect produced by starch depends on the compressibility of the constituent material and the pressure used to form the tablet.