Some physico-chemical properties of SKF 525-A in aqueous solution

Abstract

Abstract The properties of solutions of SKF 525-A (β-diethylaminoethyl diphenylpropylacetate hydrochloride) have been investigated using surface tension, light scattering and microelectrophoretic techniques. The interaction of the drug with cholesterol and lecithin monolayers was studied by a surface balance method. SKF 525-A is more surface-active than chlorpromazine, and forms micelles containing 22 monomers in 0·9% NaCl solution. It increases the surface pressure of L-α-lecithin monolayers spread on water and both L-α-lecithin and cholesterol monolayers spread on 0·9% NaCl solutions at 1–2 × 10−6M concentration levels. Because of the surface-active properties of SKF 525-A caution is urged in the interpretation of enzyme inhibition results as surfactants are well known as a class to greatly affect enzyme systems.