Affiliation:
1. Department of Clinical Pharmacology, St Bartholomew's Hospital, London EC1A 7BE, UK
Abstract
Abstract
Buccal absorption of morphine sulphate and morphine-3-glucuronide at various buffer pH values (4 to 10) over 5 min has been investigated in seven and four normal healthy volunteers, respectively. Increasing pH caused an increase in buccal absorption of both. The maximum mean absorption was 37% at pH 10 for morphine and 19% at pH 8 for morphine-3-glucuronide.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
26 articles.
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