Changes in glutathione and its metabolizing enzymes in human erythrocytes and lymphocytes with age-Reference-Cited by-同舟云学术

Changes in glutathione and its metabolizing enzymes in human erythrocytes and lymphocytes with age

Published:1987-01 Issue:1 Volume:39 Page:13-16
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Al-Turk Walid A¹,Stohs Sidney J²,El-Rashidy Fatma H²,Othman Sadeq¹

Affiliation:

1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Jordan, Amman, Jordan

2. Department of Biomedicinal Chemistry, University of Nebraska Medical Center, Omaha, Nebraska 68105, USA

Abstract

Abstract The levels of glutathione (GSH) and the activities of glutathione S-transferases (GST) and glutathione reductase (GSR) in human erythrocytes and lymphocytes were determined in three age groups (5–12, 25–40, 65–83 years). The levels of GSH in lymphocytes increased with age, however, its levels in erythrocytes reached a maximum in the middle age group. The activity of GST in erythrocytes and lymphocytes changed as a function of age in a pattern similar to the changes found for GSH levels. GSR activity increased from young to middle age in both erythrocytes and lymphocytes, but decreased again in the old age group.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/39/1/13/37541494/j.2042-7158.1987.tb07154.x.pdf

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