Prostaglandin D2-induced catalepsy in rats: role of 5-hydroxytryptamine-Reference-Cited by-同舟云学术

Prostaglandin D2-induced catalepsy in rats: role of 5-hydroxytryptamine

Published:1987-09 Issue:9 Volume:39 Page:743-745
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Bhattacharya S K¹,Rao P J R Mohan¹

Affiliation:

1. Neuropharmacology Laboratory, Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

Abstract

Abstract Prostaglandin D2 (PGD2), the major PG in the rat brain, induced a dose-related catalepsy in rats on intracerebroventricular (i.c.v.) administration. This cataleptic response was significantly attenuated following the i.c.v. administration of pharmacological agents that decrease rat brain 5-hydroxytryptamine (5-HT) activity. PGE1 synergized but PGF2α antagonized the catalepsy induced by PGD2. PGD2 and PGE1 have previously been shown to augment rat brain 5-HT activity, whereas PGFα inhibited it. It is therefore likely that the observed effects of these PGs on catalepsy involve a central 5-HT mechanism.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/39/9/743/37545290/j.2042-7158.1987.tb06983.x.pdf

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