Effect of lapachol, a naphthaquinone isolated from Tectona grandis, on experimental peptic ulcer and gastric secretion-Reference-Cited by-同舟云学术

Effect of lapachol, a naphthaquinone isolated from Tectona grandis, on experimental peptic ulcer and gastric secretion

Published:1987-02 Issue:2 Volume:39 Page:138-140
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Goel R K¹,Pathak N K R²,Biswas M²,Pandey V B²,Sanyal A K¹

Affiliation:

1. Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India

2. Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India

Abstract

Abstract Lapachol, a naphthaquinone isolated from the roots of Tectona grandis given at a dose of 5 mg kg−1 p.o. twice daily for 3 days was found to have an anti-ulcerogenic effect on subsequently induced experimental gastric and duodenal ulcers in rats and guinea-pigs. Its action appears to be associated with an effect on the protein content of gastric juice, and it reversed aspirin-induced changes in peptic activity, protein and sialic acid.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/39/2/138/37543693/j.2042-7158.1987.tb06962.x.pdf

Reference16 articles.

1. Immobilization stress in rats: Effect on rectal temperature and possible role of brain monoamines in hypothermia

2. Naturally occurring quinones. Part XII. Extractives from Tabebuia chrysantha nichols and other bignoniaceae

3. EFFECTS OF PROPRANOLOL ON GASTRIC SECRETION IN ALBINO RATS

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