Biodegradable microspheres: polyacryl starch microparticles as a delivery system for the antileishmanial drug, sodium stibogluconate-Reference-Cited by-同舟云学术

Biodegradable microspheres: polyacryl starch microparticles as a delivery system for the antileishmanial drug, sodium stibogluconate

Published:1987-10 Issue:10 Volume:39 Page:832-835
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Baillie A J¹,Coombs G H²,Dolan T F¹,Hunter C A²,Laakso T³⁴,Sjöholm I⁴,Stjärnkvist P³⁴

Affiliation:

1. Department of Pharmacy, University of Strathclyde, Glasgow G1 1XW, UK

2. Department of Zoology, University of Glasgow, Glasgow G12 8QQ, UK

3. Department of Pharmaceutical Biochemistry, Biomedical Centre, University of Uppsala, S-751 23 Uppsala

4. Division of Pharmacy, National Board of Health and Welfare, S-751 Uppsala, Sweden

Abstract

Abstract Liver parasite burdens of Leishmania donovani in the mouse have been determined after treatment with intravenous administration of sodium stibogluconate in the free or carrier form. The carrier form, in which the drug was covalently bound to polyacryl starch microparticles, was up to 100 x more effective than the free form in this murine model of visceral leishmaniasis. Empty microparticles had no effect on liver parasite burdens and the enhanced in-vivo antileishmanial activity of the carrier form of the drug was apparently due to passive drug delivery to the infected liver.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/39/10/832/37535882/j.2042-7158.1987.tb05126.x.pdf

Reference10 articles.

1. Delivery of liposome-encapsulated drugs to macrophages

2. Characterization of Polyacryl Starch Microparticles as Carriers for Proteins and Drugs

3. Non-ionic surfactant vesicles, niosomes, as a delivery system for the anti-leishmanial drug, sodium stibogluconate

4. Immobilization of proteins in microspheres of biodegradable polyacryldextran

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