Myrtenal inhibits acetylcholinesterase, a known Alzheimer target

Abstract

Abstract Objectives Inhibition of acetylcholinesterase (AChE) is a common treatment for early stages of the most general form of dementia, Alzheimer's disease. In this study selected components of essential oils, which carry a variety of important functional groups, were tested for their in-vitro anti-acetylcholinesterase activity. Methods In-vitro anti-acetylcholinesterase activity was measured by an adapted version of Ellman's colorimetric assay. Key findings 1,8-cineole, carvacrol, myrtenal and verbenone apparently inhibited AChE; the highest inhibitory activity was observed for myrtenal (IC50 = 0.17 mm). This is the first study showing the AChE inhibitory activity of myrtenal. Conclusions Our investigations provided evidence for the efficacy of monoterpenes as inhibitors of AChE.