Affiliation:
1. Food and Drug Laboratories, Department of National Health and Welfare, Ottawa, Canda
Abstract
Abstract
Maximum amounts of liothyronine and thyroxine were released from pork thyroid by the proteolytic action of erepsin and trypsin after incubation for 96 hr. at 39°. The iodinated thyronines were extracted from the hydrolysate with butanol, separated chromatographically, eluted from the paper and measured quantitatively by a chemical method in which the reduction of ceric ion by arsenious acid is catalysed by the iodine containing compounds. The iodine found in liothyronine and thyroxine accounted for 18 to 25 per cent of the total organic iodine in pork thyroid. It is postulated that pork thyroglobulin contains approximately 1 molar residue of liothyronine and 2 molar residues of thyroxine.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
32 articles.
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