Ultrasonic Irradiation of Some Phospholipid Sols

Author:

Saunders L1,Perrin J1,Gammack D2

Affiliation:

1. Department of Chemistry, School of Pharmacy, University of London, Brunswick Square, London, W.C.1

2. Institute of Psychiatry, Maudsley Hospital, Denmark Hill, London, S.E.5

Abstract

Abstract Ultrasonic irradiation of turbid sols of egg lecithin and of highly unsaturated synthetic lecithins, breaks down the large particles in the sols into micelles of micellar weight of about 5 × 106. The irradiated sols are clear and do not show any great increase of turbidity over a period of several days; they are capable of solubilising large quantities of cholesterol. The size and shape of micelles in the irradiated sols has been studied by means of viscosity and diffusion measurements and by determination of sedimentation coefficients in the ultra-centrifuge.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

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