The Effect of Ortho Substitution on the Pharmacology of Benzoylcholine

Abstract

Abstract The effects of mono- and di-ortho substitution of benzoylcholine on actions on the rat phrenic diaphragm and frog rectus abdominis preparations have been examined. Ortho substitution of benzoylcholine does not necessarily lead to a reduction in activity and may increase potency. It appears that mono-ortho-iodo substitution provides most stability combined with pharmacological activity.