Affiliation:
1. Department of Pharmacology, University of Melbourne
Abstract
Abstract
Tetrahydro-5-aminoacridine and four compounds representing its structural fragments have been compared as inhibitors of acetylcholinesterase and of monoamine oxidase. The entire structure of tetrahydro-5-aminoacridine appears to be essential for optimal inhibition of the esterase, less than 10−6 m concentration showing a 50 per cent inhibition of the enzyme, with the inhibition constant Ki as 1 × 10−4. For optimum inhibition of monoamine oxidase, the 4-aminoquinoline part of the acridine molecule appears to be a structural requirement. 4-Arninoquinoline shows a stronger monoamine oxidase inhibition than any known therapeutically used inhibitor. It gives a 50 per cent inhibition of the oxidase in 10−6 m concentration, with ki as 1.1 × 10−5.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
62 articles.
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