The Analysis of Poldine Methyl Methosulphate by Infra-Red Spectroscopy

Abstract

Abstract An assay of the drug poldine methyl methosulphate (Nacton, 2-benziloyloxymethyl-1, 1-dimethylpyrrolidinium methyl sulphate) is described, based on absorption measurements in the infra-red region of the spectrum. Absorption bands at 5·72, 7·79, 8·13, 9·84, 13·60 and 14·23 μ may be used, the first of which, however, is favoured. The method is no less accurate, and is quicker and more informative than that of Singleton and Wells, with which it is compared. The calculation of drug purity from an absorption band at one wavelength and the use of the ratio of drug purities calculated from the other bands is discussed in relation to standardisation.