Effect of verapamil and diltiazem on isolated gastro-oesophageal sphincter of the rat-Reference-Cited by-同舟云学术

Effect of verapamil and diltiazem on isolated gastro-oesophageal sphincter of the rat

Published:1985-03 Issue:3 Volume:37 Page:208-209
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Morales-Olivas Francisco J¹,Cortijo Julio¹,Esplugues Juan Vicente¹,Rubio Elena¹,Esplugues Juan¹

Affiliation:

1. Departamento de Farmacologia, Facultad de Medicina, Avda. Blasco Iban̄ez, 15, 46010 Valencia, Spain

Abstract

Abstract The effect of verapamil and diltiazem on the contraction induced by agonists on the rat lower oesophageal sphincter in-vitro has been studied. Both calcium entry blockers inhibited the contractile response to acetylcholine, carbachol and KCl. The potency of the inhibitory action was diltiazem > verapamil. The results give substance to the use of calcium entry blockers in the treatment of oesophageal spasm.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/37/3/208/37531920/j.2042-7158.1985.tb05044.x.pdf

Reference12 articles.

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4. The Mechanics of Esophageal Muscle Contraction. EVIDENCE OF AN INOTROPIC EFFECT OF GASTRIN

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