Affiliation:
1. Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria
Abstract
Abstract
The effect of ifenprodil on the contractile responses of the rat anococcygeus muscle to noradrenaline, methoxamine, carbachol, potassium chloride and calcium chloride has been examined. Ifenprodil (10−8-10−7M) non-competitively antagonized noradrenaline and methoxamine-induced contractions while carbachol-induced responses were unaffected. Similarly, contractile responses to KCl (in tissues from reserpinized animals, or tissues bathed in Tyrode containing 10−6M phentolamine) and CaCl2 in tissues bathed with Ca2+-free depolarizing solution were blocked non-competitively by ifenprodil (10−7-10−6M). These findings suggest that ifenprodil possesses α-adrenoceptor antagonist activity, with intrinsic Ca2+ blocking properties.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
20 articles.
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