Similarities in the release rates of different drugs from polyethylene glycol 6000 solid dispersions

Author:

Dubois Jean-Luc1,Ford James L2

Affiliation:

1. Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris V René Descartes, 4 Avenue de l'Observatoire, 75270 Paris Cedex 06, France

2. School of Pharmacy, Liverpool Polytechnic, Byrom Street, Liverpool L3 3AF, UK

Abstract

Abstract The dissolution rates (mg min−1) of 10 drugs, solid dispersed by fusion in polyethylene glycol 6000 (PEG 6000) have been examined by rotating disc methodology. The dispersions generally displayed release rates which were linearly dependent upon the drug concentration (% drug) at high polymer content. However the range over which this linearity was encountered varied unduly, e.g. 0–2% for phenylbutazone and 0–15% for paracetamol. The slope of this line (mean value: 0.451 mg min−1 %−1) was statistically the same for nine of the drugs studied, the exception being griseofulvin which did not form a true solid dispersion but was a microcrystatline dispersion of the drug within the PEG. During fusion, chain scission of the PEG 6000 occurred in the presence of several drugs. PEG 6000 was incompatible with disulfiram, frusemide, chlorothiazide and chlorpropamide.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

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