Effect of implanted ethylene-vinyl alcohol copolymer matrices containing 5-fluorouracil on Ehrlich ascites carcinoma-Reference-Cited by-同舟云学术

Effect of implanted ethylene-vinyl alcohol copolymer matrices containing 5-fluorouracil on Ehrlich ascites carcinoma

Published:1985-01 Issue:1 Volume:37 Page:64-66
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Miyazaki Shozo¹,Takeuchi Shigemi¹,Sugiyama Mieko¹,Takada Masahiko¹,Hosokawa Masuo²,Koga Yutaka²,Kobayashi Hiroshi²

Affiliation:

1. Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University, Ishikari-Tohbetsu, Hokkaido 061-02, Japan

2. School of Medicine, University of Hokkaido, Sapporo, Hokkaido 060, Japan

Abstract

Abstract The antitumour activity of ethylene-vinyl alcohol (EVAl) copolymer matrices containing 5-fluorouracil (5-FU) was evaluated against Ehrlich ascites carcinoma in mice. A prolongation of the life-span of tumour-bearing mice following intraperitoneal implantation of therapeutic matrices was noted. These results indicated that EVAl matrices containing 5-FU may be effective in cancer chemotherapy. Matrices composed of EVAl copolymer could be useful vehicles for implanted, inserted, or surface-applied delivery systems for anticancer agents.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/37/1/64/37531953/j.2042-7158.1985.tb04935.x.pdf

Reference14 articles.

1. Hydron: An Implantable Device for the Delivery of Antitumor Chemotherapy

2. Rate of Release of Medicaments from Ointment Bases Containing Drugs in Suspension

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