Gastrointestinal neurotensin receptors: lack of modulation by thyrotropin releasing hormone-Reference-Cited by-同舟云学术

Gastrointestinal neurotensin receptors: lack of modulation by thyrotropin releasing hormone

Published:1985-06 Issue:6 Volume:37 Page:425-428
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Donoso M Veronica¹,Huidobro-Toro J Pablo¹

Affiliation:

1. Laboratory of Pharmacology, Department of Physiological Sciences, Faculty of Biological Sciences, Catholic University of Chile, Casilla 114-D, Santiago 1, Chile

Abstract

Abstract To examine whether thyrotropin releasing hormone (TRH) antagonized gastrointestinal neurotensin receptors in isolated segments of the rat fundus, duodenum and ileum, tissues were superfused, mounted and the isometric tension recorded. Picomoles of neurotensin caused concentration-dependent contractions of the fundus and relaxation of the smooth muscles of the small intestine. Preincubation with 1–10 μm TRH failed to antagonize the activity of neurotensin but potentiated neurotensin-induced relaxation of the ileum. Pretreatment of the tissues with 0.6 μm of neuropeptide fragment 1–11, also failed to block the neurotensin-induced effects but produced a significant potentiation of the relaxant action of neurotensin.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/37/6/425/37526583/j.2042-7158.1985.tb03029.x.pdf

Reference19 articles.

1. The amino acid sequence of radioimmunoassayable neurotensin from bovine intestine.

2. Evidence for neurotensin as a non-adrenergic, non-cholinergic neurotransmitter in guinea pig ileum

3. Isolation of human intestinal neurotensin.

4. Neurotensin-induced antinociception and hypothermia in mice: antagonism by TRH and structural analogs of TRH

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Extracellular calcium dependence of the neurotensin-induced relaxation of intestinal smooth muscles: Studies with calcium channel blockers and BAY K-8644;European Journal of Pharmacology;1987-03

2. Involvement of calcium channels in the contractile activity of neurotensin but not acetylcholine: studies with calcium channel blockers and Bay K 8644 on the rat fundus;British Journal of Pharmacology;1986-08

3. Gastrointestinal neurotensin receptors: contribution of the aromatic hydroxyl group in position 11 to peptide potency;British Journal of Pharmacology;1986-03