5-Hydroxytryptamine receptor antagonism by metoclopramide and ICS 205–930 in the guinea-pig leads to enhancement of contractions of stomach muscle strips induced by electrical field stimulation and facilitation of gastric emptying in-vivo-Reference-Cited by-同舟云学术

5-Hydroxytryptamine receptor antagonism by metoclopramide and ICS 205–930 in the guinea-pig leads to enhancement of contractions of stomach muscle strips induced by electrical field stimulation and facilitation of gastric emptying in-vivo

Published:1985-09 Issue:9 Volume:37 Page:664-667
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Buchheitt K H¹,Costall B²,Engel G¹,Gunning S J²,Naylor R J²,Richardson B P¹

Affiliation:

1. Sandoz Limited, Pharmaceutical Division, Preclinical Research, Basle, Switzerland

2. Postgraduate School of Studies in Pharmacology, University of Bradford, Bradford, BD7 1DP, UK

Abstract

Abstract Contractions induced by electrical field stimulation of isolated circular muscle strips, taken from the guinea-pig stomach, were enhanced by metoclopramide, ICS 205–930 and MDL 72222 at concentrations similar to those shown to antagonize at neuronal 5-hydroxytryptamine receptor sites in a variety of preparations. Metoclopramide, MDL 72222 and ICS 205–930 also facilitated gastric emptying in-vivo. The abilities of metoclopramide, MDL 72222 and ICS 205–930 to enhance stomach muscle contraction processes and to facilitate gastric emptying may be the consequence of 5-hydroxytryptamine receptor antagonism.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/37/9/664/37533046/j.2042-7158.1985.tb05109.x.pdf

Reference22 articles.

1. Effects of metoclopramide on isolated guinea-pig colon. 2)Interference with ganglionic stimulant drugs

2. Study of the contractile effect of 5-hydroxytryptamine (5-HT) in the isolated longitudinal muscle strip from guinea-pig ileum

3. A central site of action for benzamide facilitation of gastric emptying

4. Neuronally mediated contraction responses of guinea-pig stomach smooth muscle preparations: Modification by benzamide derivatives does not reflect a dopamine antagonist action

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