The binding of flurbiprofen to plasma proteins-Reference-Cited by-同舟云学术

The binding of flurbiprofen to plasma proteins

Published:1985-09 Issue:9 Volume:37 Page:644-646
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Aarons Leon¹,Khan Azhar Z¹,Grennan David M²,Alam-Siddiqi Masooma²

Affiliation:

1. Pharmacy Department, University of Manchester, Manchester M13 9PL

2. University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford, UK

Abstract

Abstract The binding of flurbiprofen to human serum albumin and normal plasma was measured using ultracentrifugation. Flurbiprofen was bound in excess of 99% in all cases. Over the concentration range normally associated with therapy the data could be adequately described by a one-site binding model. The association constant decreased with increasing protein concentration, being 3.04 times 106 M− 1 at an albumin concentration of 2 g/100 ml and 1.19 times 106 M− 1 at a concentration of 4 g/100 ml. Flurbiprofen binding showed no dependence on pH over the range 7.0 to 8.0.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/37/9/644/37533020/j.2042-7158.1985.tb05101.x.pdf

Reference6 articles.

1. The binding of ibuprofen to plasma proteins

2. Scatchard Plots with a Positive Slope and Role of Albumin Concentration

3. Serum concentrations of flurbiprofen in rheumatoid patients receiving flurbiprofen over long periods of time

4. Antirheumatic Drug Concentrations in Human Synovial Fluid and Synovial Tissue

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