The polarography of cephalosporin C derivatives

Abstract

Abstract WE report some preliminary measurements on the polarographic reduction of cephalosporin C, cephalothin [7-(2-thienylacetamido)-cephalosporanic acid] and cephaloridine [7-(2-thienylacetamido)-3-(1-pyridylmethyl)-3-cephem-4-carboxylic acid betaine]. Green, Page & Staniforth (1965) have shown that cephalosporin C derivatives give well-defined infrared and nuclear magnetic resonance spectra that can be used for their qualitative identification. Martin & Shaw (1965) have reviewed the application of methods such as ultraviolet spectrophotometry, paper chromatography and paper electrophoresis for cephaloridine, while Chapman, Page & others (1968) have described infrared and X-ray powder measurements for this compound. The application of mass spectroscopy to the structural elucidation of cephalosporin derivatives has been reported by Richter & Biemann (1965).