The assignment of absolute configurations to the individual enantiomorphs of phenylpropylmethylamine and pipradrol hydrochloride-Reference-Cited by-同舟云学术

The assignment of absolute configurations to the individual enantiomorphs of phenylpropylmethylamine and pipradrol hydrochloride

Published:1968-02 Issue:2 Volume:20 Page:87-91
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Hemingway R J¹

Affiliation:

1. School of Pharmacy, University of London, Brunswick Square, London, W.C.1, England

Abstract

Abstract The configuration of the C-2 asymmetric centre of (—)-phenylpropylmethylamine (N-methyl-2-phenylpropylamine) has been related by a stereospecific route to that of the analogous centre of (+)-(S)-hydratropic acid. The configuration at the C-2 asymmetric centre of (—)-pipradrol (diphenylpiperid-2-ylmethanol) hydrochloride has been related by a stereospecific route to that of the analogous centre of (+)-(R)-pipecolic acid.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/20/2/87/37697768/j.2042-7158.1968.tb09694.x.pdf

Reference14 articles.

1. 194. The mechanism of the Hofmann reaction. Retention of optical activity during the reaction with (+)hydratropamide

2. 32. The hydratropic acids and the related 2-phenylpropanols

3. Chemical structure and sympathomimetic action of amines

4. The Common Basis of Intramolecular Rearrangements. V.1 Inversion of Configuration in Semipinacolic Deamination. The Configurational Relationship between (+)-Alanine and (+)-Methylphenylacetic Acid

5. 618. Thiohydantoins. Part IV. The action of Raney nickel on some monothiohydantoins

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