Some aspects of the pharmacology of ibufenac, a non-steroidal anti-inflammatory agent

Abstract

Abstract When given orally to animals ibufenac has a range of potencies 2 to 4 times that of aspirin. It also suppresses thurfyl nicotinate erythema in man. Like certain other analgesic-anti-inflammatory-antipyretic drugs, when administered intravenously it suppresses bradykinin-induced bronchoconstriction in the guinea-pig. It has no glucocorticoid activity. Ibufenac, a compound chemically unrelated to existing antirheumatic drugs, can thus be classified as a non-steroidal anti-inflammatory (antirheumatic) agent.