Affiliation:
1. Department of Pharmacology, University of Melbourne, Parkville, Victoria 3052, Australia
Abstract
Abstract
Chromatographs of extracts of urine from patients receiving mixtures of morphine plus amiphenazole or morphine plus 1, 2, 3, 4-tetrahydro-9-aminoacridine (tha) have a spot which is due to a substance with properties similar to morphine-N-oxide. This spot was not present in urine of patients given morphine, amiphenazole or tha alone. Morphine-N-oxide may be a metabolite of morphine, and amiphenazole and tha may inhibit the further metabolism of morphine-N-oxide.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
19 articles.
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