The effect of antirheumatic drugs on the extractable collagen in lathyric chick embryos

Author:

Trnavský K1,Trnavskñ Z1

Affiliation:

1. Research Institute of Rheumatic Diseases, Piešt̆any, Czechoslovakia

Abstract

Abstract The lathyrogenic effect of 2·5 mg of β-aminopropionitrile in the chick embryo has been measured by the increase in the extractability of collagen from bones using M saline. Sodium salicylate (3 mg/embryo) and hydrocortisone (1·5 mg/embryo) applied 24 hr after the injection of β-aminopropionitrile decreased the elevated amount of soluble collagen. Phenylbutazone, chloroquine diphosphate and sodium aurothiosulphate were ineffective in this experimental system.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Recent developments in disease-modifying antirheumatic drugs;Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques;1980

2. Some Effects of Antiinflammatory Drugs on Connective Tissue Metabolism;Anti-inflammatory Agents;1974

3. Nineteenth rheumatism review. Part-III;Arthritis & Rheumatism;1970-09

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