Affiliation:
1. Biomedical Sciences Division, King's College London, Strand, London WC2R 2LS, UK
Abstract
Abstract
The presence of the blood-brain barrier (BBB), reduces the brain uptake of many drugs, peptides and other solutes from blood. Strategies for increasing the uptake of drugs and peptide-based drugs include; structural modifications to increase plasma half-life; improving passive penetration of the BBB by increasing the lipophilicity of the molecule; designing drugs which react with transporters present in the BBB; and reducing turnover and efflux from the central nervous system (CNS).
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
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