Trifluoperazine is More Effective than Chlorpromazine in Releasing Oxygen from Haemoglobin and Myoglobin-Reference-Cited by-同舟云学术

Trifluoperazine is More Effective than Chlorpromazine in Releasing Oxygen from Haemoglobin and Myoglobin

Published:1996-09 Issue:9 Volume:48 Page:965-967
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Bhattacharyya Jaya¹,Bhattacharyya Maitree¹,Chakraborti Abhay Sankar¹,Chaudhuri Utpal¹,Poddar Ramendra Kumar¹

Affiliation:

1. Department of Biophysics, Molecular Biology & Genetics, University of Calcutta, 92, Acharyya Prafulla Chandra Road, Calcutta 700 009, India

Abstract

Abstract The extent of oxygen release from two heme proteins, haemoglobin and myoglobin have been studied in the presence of trifluoperazine and chlorpromazine (5–1000 μM). At a molar ratio (drug: protein) of 1.5, the release of oxygen from haemoglobin was 4 and 15% in the presence of chlorpromazine and trifluoperazine respectively, while from myoglobin the corresponding values were 20 and 40%. The findings were attributed to the greater extent of local conformational change around tryptophan moieties of each of the proteins induced by trifluoperazine.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/48/9/965/37017279/j.2042-7158.1996.tb06013.x.pdf

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