Effect of Mn2+ on the Development of Tension Induced in Guinea-pig Taenia Coli by Bay K 8644

Author:

Nasu Tetsuyuki1,Sasaki Miyori1

Affiliation:

1. Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753, Japan

Abstract

Abstract We have studied the effects of Mn2+ on the contractile response induced by Bay K 8644, a dihydropyridine Ca2+ agonist, on guinea-pig taenia coli. Mn2+ (5 mm) completely inhibited Bay K 8644 (10−6  m)-induced rhythmic contraction and contracture to baseline values in normal Ca2+ medium; thereafter, the contraction progressively increased to about 90% of the K+ (60 mm)-induced tonic response. In Ca2+-free medium in the presence of Bay K 8644 Mn2+ also evoked contraction and a concomitant increase in Mn2+ influx into the cytoplasm. These results suggest that during the opening of voltage-dependent Ca2+ channels activated by Bay K 8644, Mn2+ can enter cytoplasm through the channels and induce contraction in taenia coli.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Reference23 articles.

1. Mechanics of guinea-pig taenia coli smooth muscle during anoxia and rigor;Bose;Am. J. Physiol.,1975

2. Distribution and kinetics of CoEDTA in smooth muscle, and its use as an extracellular marker;Brading;J. Physiol.,1969

3. Membrane potential changes associated with tachyphylaxis and potentiation of the response to stimulating drugs in smooth muscle;Bülbring;Br. J. Pharmacol.,1960

4. The superficial buffer barrier in venous smooth muscle: sarcoplasmic reticulum refilling and unloading;Chen;Br. J. Pharmacol.,1993

5. The effects of manganese on the rabbit anterior mesenteric-portal vein;Collins;Can. J. Physiol. Pharmacol.,1972

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