Affiliation:
1. Biological Laboratories, The British Drug Houses Ltd., Godalming, Surrey
Abstract
Summary
An investigation on animals of the toxicological and pharmacological properties of piperazine adipate, a new anthelmintic agent, is reported. It is comparatively non-toxic orally, the LD50 of mice and rats being 11·4 and 7·9 g./kg. respectively. It has a spasmogenic action on isolated intestinal muscle and intestinal muscle in situ when large doses are given. Cardiac, circulatory and respiratory effects were slight, the rapid intravenous injection of large amounts being required to produce a response. 5 It has been safely administered over a prolonged period to rats and rabbits.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
8 articles.
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