The effect of the photodecomposition of chlorpromazine on lecithin monolayers-Reference-Cited by-同舟云学术

The effect of the photodecomposition of chlorpromazine on lecithin monolayers

Published:1978-09 Issue:1 Volume:30 Page:748-753
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Nejmeh Maha¹,Pilpel N¹

Affiliation:

1. Department of Pharmacy, Chelsea College, University of London, Manresa Road, London, SW3 6LX, UK

Abstract

Abstract Chlorpromazine hydrochloride (cpz) is decomposed when irradiated with ultraviolet light, forming H+, hydrochloric acid, chlorpromazine sulphoxide and 2-hydroxypromazine. The order of the reaction (as measured by the expansion that is produced in a lecithin/cpz monolayer) varies between zero and about 3/4. The results have been used to explain some of the adverse side effects that are observed when patients are treated with cpz.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/30/1/748/37759422/j.2042-7158.1978.tb13385.x.pdf

Reference22 articles.

1. Role of Lysosomes and of Cell Membranes in Photosensitization

2. On Chlorpromazine Binding in vivo**From the Department of Dermatology, Stanford University School of Medicine, Stanford, California.

3. A Study of Photosensitivity Occurring with Chlorpromazine Therapy11Presented at the Seventeenth Annual Meeting of The Society for Investigative Dermatology, Inc., Chicago, Illinois, June 10, 1956.

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