Studies on the role of ACTH and of 5-HT in anxiety, using an animal model-Reference-Cited by-同舟云学术

Studies on the role of ACTH and of 5-HT in anxiety, using an animal model

Published:1978-09 Issue:1 Volume:30 Page:105-110
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

File Sandra E¹,Vellucci Sandra V¹

Affiliation:

1. Department of Pharmacology, The School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX, UK

Abstract

Abstract The effects of ACTH (5 & 7·5 μg/100 g) were studied using a new animal model of anxiety. ACTH had an anxiogenic effect that was maximal during a 10 min test period starting 3 min after injection. The behavioural effects of ACTH were counteracted by chronic administration of chlordiazepoxide (5 mg kg−1 for 5 days) and by acute administration of ethanol (0·4 g kg−1). These anxiolytic drugs decreased the turnover of 5-HT in the midbrain, hypothalamus and cerebral cortex, whereas ACTH increased 5-HT turnover in the midbrain and hypothalamus. It is therefore proposed that anxiety results from the action of ACTH, possibly on 5-HT pathways in the midbrain and hypothalamus.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/30/1/105/37759124/j.2042-7158.1978.tb13172.x.pdf

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