Oscillations of C‐peptide in the euglycemic clamp and their effect on the pharmacodynamic assessment of insulin preparations
Author:
Affiliation:
1. Department of Endocrinology and Metabolism West China Hospital of Sichuan University 37 Guoxue Alley, Wuhou District Chengdu Sichuan China
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/fcp.12628
Reference30 articles.
1. BeckerR.H.Pharmacodynamic Evaluation: Diabetes Methodologies: Methods in Clinical Pharmacology. Drug Discovery and Evaluation: Methods in Clinical Pharmacology 2011 pp.457–81.
2. AgencyE.M.Guideline on non‐clinical and clinical development of similar biological medicinal products containing recombinant human insulin and insulin analogues.2015.
3. The euglycemic hyperinsulinemic clamp examination: variability and reproducibility
4. Assessment of Glucose Turnover Rates in Euglycaemic Clamp Studies using Primed-constant [3-3H]-glucose Infusion and Labelled or Unlabelled Glucose Infusates
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3. Commentary: Reduction in C-Peptide Levels and Influence on Pharmacokinetics and Pharmacodynamics of Insulin Preparations: How to Conduct a High-Quality Euglycemic Clamp Study;Frontiers in Pharmacology;2022-02-18
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