Afatinib‐induced toxic epidermal necrolysis: A case report with a literature review-Reference-Cited by-同舟云学术

Afatinib‐induced toxic epidermal necrolysis: A case report with a literature review

Published:2024-05-27 Issue:8 Volume:90 Page:2030-2033
ISSN:0306-5251
Container-title:British Journal of Clinical Pharmacology
language:en
Short-container-title:Brit J Clinical Pharma

Author:

Belančić Andrej¹²^ORCID,Hlača Nika³⁴,Peternel Sandra³⁴,Golčić Marin⁵,Prpić‐Massari Larisa³⁴,Vlahović‐Palčevski Vera¹²

Affiliation:

1. Department of Clinical Pharmacology Clinical Hospital Centre Rijeka Rijeka Croatia

2. Department of Basic and Clinical Pharmacology With Toxicology, Faculty of Medicine University of Rijeka Rijeka Croatia

3. Department of Dermatovenerology Clinical Hospital Centre Rijeka Rijeka Croatia

4. Department of Dermatovenerology, Faculty of Medicine University of Rijeka Rijeka Croatia

5. Department of Radiotherapy and Oncology Clinical Hospital Centre Rijeka Rijeka Croatia

Abstract

We present a 70‐year‐old female patient diagnosed with epidermal growth factor receptor‐mutated metastatic non‐small cell lung cancer (T4N2M1a), who developed afatinib‐induced toxic epidermal necrolysis (TEN). We have also performed a PubMed/Medline literature review to detect other possible cases of TEN/Stevens–Johnson syndrome associated with afatinib treatment and found only 5 other cases reported. To our best knowledge, this is the first case of afatinib‐induced TEN successfully treated with cyclosporine.

Publisher

Wiley

Link

https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/bcp.16114

Reference24 articles.

1. Giotrif (afatinib) film‐coated tablets: EU summary of product characteristics. Accessed November 20 2023.https://www.ema.europa.eu/en/medicines/human/EPAR/giotrif

2. Phase III Study of Afatinib or Cisplatin Plus Pemetrexed in Patients With Metastatic Lung Adenocarcinoma With EGFR Mutations

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Afatinib;Reactions Weekly;2024-08-24