Affiliation:
1. The School of Biomedical and Pharmaceutical Engineering Guangdong University of Technology Guangzhou China
2. Infinitus Company Ltd., R&D Center Guangzhou China
3. Foshan Conney Allan Biotechnology Co. Ltd Foshan China
4. State Key Laboratory Basis of Xinjiang indigenous medicinal plants resource utilization, CAS Key Laboratory of Chemistry of Plant Resources in Arid Regions Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi China
5. University of Chinese Academy of Sciences Beijing China
Abstract
AbstractBackground and AimsSolar lentigo is a prevalent skin condition that affects a significant number of individuals. Fortunately, certain traditional Chinese medicines and monomers (TCMM) have proven effective in addressing these concerns. In this study, we evaluated the efficacy and underlying mechanism of TCMM, a combination of TCM and monomers in repairing solar lentigo.MethodsWe detected and identified the main compounds of TCM using liquid chromatography‐mass spectrometry (LC–MS) and through the approach of network pharmacology, we screened drug and disease targets, visualized networks with Cytoscape software, analyzed targets via Gene ontology and KEGG, clinically validated predictions. In a mouse model, UVB‐induced pigmentation was assessed, and the effects of TCMM were evaluated. A clinical trial on 30 patients validated the depigmenting agent.ResultsActive ingredients such as MSH, Butylated hydroxytoluen, Valerophenone, and Geranylacetone aid pigmentation treatment. One hundred and forty‐three crore targets impact PI3K‐Akt, MAPK signaling pathway, ect. pathways. TCMM reduced UVB‐induced pigmentation, water loss, epidermal thickness, and melanin. It inhibited TYR, MITF, AKT1, VEGFA, PTGS2, TNF‐α, IL‐6, IL‐1β. Clinical and microscopic analysis showed significant pigmentation reduction.ConclusionsThe treatment of solar lentigo can benefit from the TCMM. By targeting multiple factors and pathways, this approach offers a comprehensive and effective treatment strategy.
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