The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulation

Author:

Liu Dong1,Zhang Yongqing2,Gharavi Robert1,Park Hee Ra3,Lee Jaewon3,Siddiqui Sana1,Telljohann Richard1,Nassar Matthew R.1,Cutler Roy G.1,Becker Kevin G.2,Mattson Mark P.1

Affiliation:

1. Laboratory of Neurosciences; National Institute on Aging Intramural Research Program; Baltimore Maryland USA

2. Gene Expression and Genomics Unit; National Institute on Aging Intramural Research Program; Baltimore Maryland USA

3. Department of Pharmacy; College of Pharmacy; Molecular Inflammation Research Center for Aging Intervention; Pusan National University; Busan Korea

Funder

National Institute on Aging

PNU's Tenure-track Faculty

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Biochemistry

Reference106 articles.

1. CREB and the CRTC co-activators: sensors for hormonal and metabolic signals;Altarejos;Nat. Rev. Mol. Cell Biol.,2011

2. Mitochondrial uncoupling proteins in the CNS: in support of function and survival;Andrews;Nat. Rev. Neurosci.,2005

3. Neurotrophins in neuroendocrine control: brain derived-neurotrophic factor (BDNF) and somatostatin involvement in the stress response and reproductive physiology;Arancibia;Annu. Rev. Biomed. Sci.,2003

4. Age and energy intake interact to modify cell stress pathways and stroke outcome;Arumugam;Ann. Neurol.,2010

5. Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism American Society for Nutrition;Baird;Adv. Nutr.,2012

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