40K glycoPEGylated, recombinant FVIIa: 3-month, double-blind, randomized trial of safety, pharmacokinetics and preliminary efficacy in hemophilia patients with inhibitors

Author:

Ljung R.1,Karim F. A.2,Saxena K.3,Suzuki T.4,Arkhammar P.5,Rosholm A.6,Giangrande P.7,

Affiliation:

1. Department of Paediatrics and Malmö Centre for Thrombosis and Haemostasis; Lund University; Skåne University Hospital; Malmö Sweden

2. Haemophilia Centre; National Blood Centre; Kuala Lumpur Malaysia

3. Children's Hospital Boston; Harvard Medical School; Boston MA USA

4. Department of Laboratory Medicine; Tokyo Medical University; Tokyo Japan

5. Medical and Science; Haemophilia R&D Portfolio; Novo Nordisk A/S; Søborg Denmark

6. Biostatistics Biopharm; Novo Nordisk A/S; Søborg Denmark

7. Oxford Haemophilia and Thrombosis Centre; Churchill Hospital; Oxford UK

Publisher

Wiley

Subject

Hematology

Reference23 articles.

1. World Federation of Hemophilia Report on the Annual Global Survey 2010 World Federation of Hemophilia http://www1.wfh.org/publications/files/pdf-1427.pdf

2. Activity and regulation of glycoPEGylated factor VIIa analogs;Ghosh;J Thromb Haemost,2008

3. Effect of glycoPEGylation on factor VIIa binding and internalization;Sen;Haemophilia,2010

4. Generation and biochemical characterization of glycoPEGylated factor VIIa derivatives;Stennicke;Thromb Haemost,2008

5. The molar hydrodynamic volume changes of factor VIIa due to GlycoPEGylation;Plesner;J Pharm Biomed Anal,2011

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