Associations of radiologic characteristics of the neonatal hypothalamus with early life adiposity gain-Reference-Cited by-同舟云学术

Associations of radiologic characteristics of the neonatal hypothalamus with early life adiposity gain

Published:2024-03-13 Issue:6 Volume:19 Page:
ISSN:2047-6302
Container-title:Pediatric Obesity
language:en
Short-container-title:Pediatric Obesity

Author:

Sewaybricker Leticia E.¹^ORCID,Melhorn Susan J.¹,Entringer Sonja²³⁴,Buss Claudia²³⁴,Wadhwa Pathik D.²³⁵⁶⁷,Schur Ellen A.¹,Rasmussen Jerod M.²³

Affiliation:

1. Department of Medicine University of Washington Seattle Washington USA

2. Development, Health and Disease Research Program University of California Irvine California USA

3. Department of Pediatrics University of California Irvine California USA

4. Department of Medical Psychology Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany

5. Department of Obstetrics and Gynecology University of California Irvine California USA

6. Department of Psychiatry and Human Behavior University of California Irvine California USA

7. Department of Epidemiology University of California Irvine California USA

Abstract

SummaryBackgroundThe mediobasal hypothalamus (MBH) is a key brain area for regulation of energy balance. Previous neuroimaging studies suggest that T2‐based signal properties indicative of cellular inflammatory response (gliosis) are present in adults and children with obesity, and predicts greater adiposity gain in children at risk of obesity.Objectives/MethodsThe current study aimed to extend this concept to the early life period by considering if, in full‐term healthy neonates (up to n = 35), MRI evidence of MBH gliosis is associated with changes in early life (neonatal to six months) body fat percentage measured by DXA.ResultsIn this initial study, neonatal T2 signal in the MBH was positively associated with six‐month changes in body fat percentage.ConclusionThis finding supports the notion that underlying processes in the MBH may play a role in early life growth and, by extension, childhood obesity risk.

Funder

Eunice Kennedy Shriver National Institute of Child Health and Human Development

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Mental Health

University of Washington Nutrition and Obesity Research Center

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/ijpo.13114

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