Revisiting Type 2-high and Type 2-low airway inflammation in asthma: current knowledge and therapeutic implications

Author:

Robinson D.1ORCID,Humbert M.2,Buhl R.3,Cruz A. A.4,Inoue H.5,Korom S.6,Hanania N. A.7,Nair P.8ORCID

Affiliation:

1. Department of Respiratory Medicine; Severe Asthma Service; UCLH NHS Trust; London UK

2. Service de Pneumologie; Hôpital Bicêtre; Assistance Publique Hôpitaux de Paris; University Paris-Sud; Université Paris-Saclay; INSERM U999; Le Kremlin-Bicêtre France

3. Pulmonary Department; Mainz University Hospital; Mainz Germany

4. ProAR-Center of Excellence in Asthma; Federal University of Bahia School of Medicine; Salvador Brazil

5. Department of Pulmonary Medicine; Graduate School of Medical and Dental Sciences; Kagoshima University; Kagoshima Japan

6. F. Hoffmann-La Roche Ltd; Basel Switzerland

7. Section of Pulmonary and Critical Care Medicine; Baylor College of Medicine; Houston TX USA

8. Division of Respirology; Department of Medicine; McMaster University; Hamilton ON Canada

Funder

AstraZeneca

Chiesi Farmaceutici

Roche

Teva Pharmaceutical Industries

Boehringer Ingelheim

GlaxoSmithKline

Novartis

Sanofi-Aventis

Merck Sharp and Dohme

Mylan

Astellas Pharma US

ChugaiPharm

Pfizer

Teijin-Pharma and Torii

AZ

Sanofi

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference177 articles.

1. Global Initiative for Asthma (GINA) Global strategy for asthma management and prevention - updated 2016 2016 http://ginasthma.org/gina-reports/

2. A summary of the new GINA strategy: a roadmap to asthma control;Reddel;Eur Respir J,2015

3. Asthma: defining of the persistent adult phenotypes;Wenzel;Lancet,2006

4. Asthma phenotypes and endotypes: an evolving paradigm for classification;Corren;Discov Med,2013

5. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome;Lotvall;J Allergy Clin Immunol,2011

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