Affiliation:
1. Department of Internal Medicine Gaziantep University Turkey
2. Department of Nuclear Medicine, Medical Faculty Gaziantep University Turkey
3. Department of Epidauros Biotechnology Pharmacognetics Laboratory Bernried Germany
Abstract
SUMMARYIt has been suggested that an insertion/deletion (I/D) polymorphism in intron 16 of the angiotensin‐converting enzyme (ACE) gene may be associated with diabetic nephropathy. The aim of this study was to investigate whether an association exists between ACE I/D polymorphism and glomerular filtration rate (GFR) in type 2 diabetes mellitus. A total of 128 type 2 diabetic patients were included in the study with the following ACE genotype distribution: DD 40, ID 58, II 30. I/D polymorphism was determined by polymerase chain reaction (PCR). Mean GFR was not statistically different according to ACE genotype (DD: 89.9 ± 28.1 ml/min, ID: 99.5 ± 25.1 ml/min, II: 96.6 ± 19.6 ml/min). There was no significant difference in genotype distribution in normo‐, micro‐ and macroalbuminuric patients (DD:ID:II [%], normo‐ 35:46:19, micro‐28:55:17, macro‐ 31:55:14). ACE I/D polymorphism does not seem to be associated with GFR in type 2 diabetic patients.