AVASCULAR NECROSIS OF BONE: THE HIDDEN RISK OF GLUCOCORTICOIDS USED AS ANTIEMETICS IN CANCER CHEMOTHERAPY-Reference-Cited by-同舟云学术

AVASCULAR NECROSIS OF BONE: THE HIDDEN RISK OF GLUCOCORTICOIDS USED AS ANTIEMETICS IN CANCER CHEMOTHERAPY

Published:2001-06 Issue:5 Volume:55 Page:344-345
ISSN:1368-5031
Container-title:International Journal of Clinical Practice
language:en
Short-container-title:Int J Clinical Practice

Author:

Virik K¹,Karapetis C¹,Droufakou S¹,Harper P¹

Affiliation:

1. Department of Medical Oncology Guy's Hospital London

Abstract

SUMMARYThe role of antiemetics is invaluable in allowing cancer patients to complete otherwise potentially intolerable chemotherapy. Corticosteroids have an established place in the prevention and treatment of nausea and vomiting due to emetogenic cytotoxic agents. Avascular necrosis of bone is a recognised complication of glucocorticoid treatment – the risk of this increasing with higher doses and longer duration of use. This report details a case of bilateral avascular necrosis of the femoral heads in a patient receiving ‘standard’ doses of dexamethasone as part of the antiemetic regimen used in cisplatin‐based combination chemotherapy.

Publisher

Wiley

Subject

General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1742-1241.2001.tb11055.x

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