Affiliation:
1. Royal Liverpool Hospital
2. Chester Royal Infirmary
3. Department of Immunology University of Liverpool
Abstract
SummaryFifty eight patients with the irritable bowel syndrome (IBS) have been investigated by skinprick testing, quantitation of total serum IgE levels and determination of serum antibodies reactive with common dietary proteins. An increased incidence of skin reactivity (48.3 per cent; p<0.05), as well as serum IgG antibodies reactive with chicken ovalbumin, bovine milk or wheat gliadin (52.6 per cent; p<0.01), was demonstrated in IBS patients compared with controls. These results provide evidence of immunological hypersensitivity in at least a proportion of IBS subjects and contrasts with the concept that IBS always results from psychological factors.
Reference13 articles.
1. ORGANIC AND FUNCTIONAL DISORDERS IN 2000 GASTROENTEROLOGY OUTPATIENTS
2. CONTROLLED TRIAL OF HYPNOTHERAPY IN THE TREATMENT OF SEVERE REFRACTORY IRRITABLE-BOWEL SYNDROME
3. Food intolerance: a major factor in the pathogenesis of irritable bowel syndrome;Alun Jones V;Lancet,1982
4. Distribution of serum antibodies to wheat gliadin and bovine milk in atopic and non‐atopic healthy adults;Barnes RMR;J Clin Lab Immunol,1983
5. Serum IgG antibodies to gliadin and other dietary antigens in adults with atopic eczema