Affiliation:
1. Servicio de Electrofisiología, Unidad Médica de Alta Especialidad Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social Universidad Nacional Autónoma de México Ciudad de México México
Abstract
AbstractIntroductionDynamic ECG changes in Brugada syndrome (BrS) are influenced by several factors, may not be apparent, and can be unmasked by a drug test.Methods and ResultsFour of six patients with nondiagnostic Brugada ECG index patterns underwent a dextrose‐insulin challenge test that resulted in J‐ST segment elevation and triggered arrhythmias.ConclusionInsulin action may be due in part to an outward shift in the K+ current at the end of action potential phase 1 and the dispersion of repolarization, leading to local re‐entry with arrhythmogenicity. This effect is likely a phenomenon‐specific to BrS.
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
Cited by
1 articles.
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1. Glucose/insulin;Reactions Weekly;2023-09-16