Sustained Increase in the Oral Bioavailability of Loperamide after a Single Oral Dose of HM30181, a P-glycoprotein Inhibitor, in Healthy Male Participants

Author:

Cha Yu-Jung1,Lee Howard2,Gu Namyi1,Kim Tae-Eun1,Lim Kyoung S.1,Yoon Seo H.1,Chung Jae-Yong1,Jang In-Jin1,Shin Sang-Goo1,Yu Kyung-Sang1,Cho Joo-Youn1

Affiliation:

1. Department of Clinical Pharmacology and Therapeutics; Seoul National University College of Medicine; Seoul National University Hospital; Seoul Korea

2. Clinical Trials Center; Seoul National University Hospital; Seoul Korea

Publisher

Wiley

Subject

Pharmacology,Toxicology,General Medicine

Reference21 articles.

1. P-glycoprotein inhibition;Darby;Curr Drug Metab,2011

2. Expression of cytochromes P450 3A and P-glycoprotein in human large intestine in paired tumour and normal samples;Canaparo;Basic Clin Pharmacol Toxicol,2007

3. Uptake/efflux transport of tramadol enantiomers and O-desmethyl-tramadol;Kanaan;Basic Clin Pharmacol Toxicol,2009

4. Modulation of P-glycoprotein mediated multidrug resistance (MDR) in cancer using chemosensitizers;Velingkar;Int J Pharma Sci Res,2010

5. Multidrug resistance in cancer;Gottesman;Nat Rev Cancer,2002

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