Association of TLR4 polymorphisms (Asp299Gly and Thr399Ile) with sepsis: a meta‐analysis and trial sequence analysis

Author:

Mu Jingjing1,Shen Yue2,Zhu Furong3,Zhang Qixia1ORCID

Affiliation:

1. Department of Critical care Medicine 330 wards The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China

2. Department of Critical Care Medicine The Sixth Medical Center of PLA General Hospital Beijing China

3. School of Nursing Wenzhou Medical University, Cixi Institute of Biomedicine Wenzhou Medical University Wenzhou China

Abstract

Several investigations have been carried out to explore the genetic association of TLR4 codon variants, specifically Asp299Gly and Thr399Ile, and susceptibility to sepsis, but the results have been contradictory. The present study aimed to conduct a meta‐analysis to draw a definitive conclusion regarding the role of TLR4 genetic variants (Asp299Gly and Thr399Ile) in sepsis. A thorough literature search was conducted using the PubMed, Scopus, and Science Direct databases. The inclusion and exclusion criteria were established to ensure the accuracy of the data. The Comprehensive Meta‐Analysis Software v4 was utilized to perform the meta‐analysis and related analyses. A total of 13 studies were analyzed, including 2328 sepsis cases and 2495 healthy controls for the TLR4 Asp299Gly variant. Eight studies provided genotype data for the rs4986791 polymorphism. The Asp299Gly variant showed a marginal protective effect in the allele (p = 0.08, odds ratio = 0.71) and dominant (p = 0.09, odds ratio = 0.71) genetic models, although it was not statistically significant. The trial sequential analysis indicated that further case–control studies are necessary to draw definitive conclusions about the TLR4 polymorphisms in sepsis. The TLR4 Asp299Gly variant may have a protective effect against sepsis. However, additional research with larger sample sizes across diverse populations is required to validate this finding.

Publisher

Wiley

Reference47 articles.

1. SARS‐CoV‐2 and acute diverticulitis: the expanding gastrointestinal manifestations of COVID‐19 infection;Weissman S;J Transl Int Med,2021

2. Impact of COVID-19 pandemic control measures on infection of other respiratory pathogens: A real-world data research in Guangzhou, China

3. The emergence of travel-related infections in critical care units

4. Upper respiratory tract infections and academic attainment: a case study;Smith AP;J Clin Transl Res,2022

5. Coronavirus disease 2019: an overview of the complications and management;Shao H;INNOSC Theran Pharmacol Sci,2021

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3